Tuberculosis (TB) is a major problem of Belarus Public Health. Recently situation has been complicated with emergence and development of MDR/XDR TB and HIV/TB which require long-term treatment. Many and the most severe cases usually disseminate across the country to different TB dispensaries. The ability of leading Belarus TB specialists to follow such patients will be greatly improved by using a common database containing patients’ radiological images, lab work and clinical data. This will also significantly improve adherence to the treatment protocol and result in a better record of the treatment outcomes.
During the past several years in Belarus there were a number of projects accomplished in the field of computerized lung disease diagnosis and treatment. In particular, there was a fully digital telemedicine system on X-ray lung screening develo ped and deployed in Minsk city, the capital of Belarus. It covers about 20% of population of the country in the compulsory lung disease screening. As a result of the few first years of operation, a large X-ray image database was created which already contains about 1 million of digital scans. Also, an experimental GRID-based computer network was developed for supporting computationally-expensive CT and X-ray image analysis task such as detecting lung tumor borders, content-based lung image retrieval in computer-aided diagnosis, image data mining, etc. These activities created a solid base for the suggested proposal, which will be implemented by specialists from leading institutions and hospitals of Belarus.
The objective of the project is to create a new open access public health resource for the tuberculsosis (TB) research and education.
Criteria for inclusion clinical cases in the database of the portal
Patients admitted to the MDR-TB department of RSPC of Pulmonology and Tuberculosis with diagnosed or suspected of MDR-TB, which conducted CT – study (± 2 months from the date of registration)
Title: “Open access information resources and the possibility of image-based detection of multiresistant tuberculosis”
Agreement number: BOB1-31055-MK-11
CRDF program: Grant Assistance Program/Focus
Authorization: Freedom Support Act
Appropriation: PL 102-511
CFDA Number: 47.079
Starting Date: September 1, 2011
Duration: 12 Month
The goal of the project is to establish the new public heath resource for TB in Belarus and to create open access information resources on tuberculosis (TB) in Belarus.
- Establish a sustainable ongoing clinical database for the Belarus TB public health program (BTBDB) based on both new data acquired from incoming patients (medical images and other clinical data) as well as extracting data from existing medical records and histories of interest.
- Establish a comprehensive large scale clinical portal (BTB Portal) for TB researchers worldwide by making the de-identified version of BTBDB available via Internet.
- Start on the analysis for using BTBDB and BTB Portal to examine the possibility of early detection of the MDR/XDR forms of TB utilizing the large dataset of the lung CT and X-ray medical images.
- Use BTBDB to further examine the possibility of early detection of the multi-resistant forms of TB utilizing its the large dataset of the lung CT and X-ray medical images.
- Expand BTBDB capability to collect clinical data by developing software to (a) add additional types of clinical data and (b) improve collection methods for supported clinical data types.
- Use BTBDB to examine the possibility of using the BTBDB medical images and other clinical data to improve TB diagnostics and treatment for TB.
The first year of the project will mostly be dedicated to the development of database structures, establishing the data collection technology, accumulating the first solid fraction of data, selection, verification and preprocessing of study groups and research materials as well as demonstration of a prototype of the open-access database.
During the second year, all the information resources will be finalized, the open-access database launched, and the hypothesis regarding the possibilities of early detecting multiresistant TB being tested in due course.
Successful implementation of the proposal is secured by the fact that it will be executed by two leading Belarusian research institutions working in the tuberculosis and ICT domains in close collaboration with NIAID OCICB
National Institute of Allergy and Infectious Diseases (NIAID)
Office of Cyber Infrastructure & Computational Biology
10401 Fenwood Road
Bethesda, MD 20817 USA
Telephone: (301) – 594-7368
United Institute of Informatics Problems of the National Academy of Sciences of Belarus (UIIP NASB)
Dept. of Mathematical Cybernetics
Dept. of Information analysis systems
Dept. of Biomedical Image Analysis
6 Surganova Str.
Minsk 220012, Belarus
157 Dolginovsky trakt
Minsk 220053, Belarus
Fax: +375-17-289-89-50, +375-17-289-84-53